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Patients take one 8 mg tablet 30 minutes before the beginning of treatment, then every 12 hours for 1 to 2 days afterward Ondansetron is an anti-nausea medication and metoclopramide is a "prokinetic" drug. Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. For prophylactic administration zofran has better numbers. Comparing Phenergan vs Zofran Phenergan (promethazine) Zofran (ondansetron) Prescription only Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. But you can actually take 4-8mg of zofran every 4-8 hours Regarding your concern I want to share with you that,Zofran contains , Ondansetron is an antiemetic (anti-nausea medicine). You can drink slightly flattened ginger ale or nibble on crystallized ginger. Side effects of ondansetron and metoclopramide that are similar include fatigue and drowsiness. Side effects of ondansetron that are different from metoclopramide include headache, feeling unwell (malaise), constipation, dizziness, diarrhea, and abnormal heart. Sedation is the main side effect Baseline nausea, anxiety, and sedation scores were similar. It's available in different forms that you don't have to swallow in case you can't keep anything down. Phenergan makes me very tired and out of it, but from what I read Zofran is mostly just for cancer/chemo patients. I have used all of these and more and found Zofran to help me. Secondary endpoints included changes in anxiety, sedation, and other adverse effects. I have nausea/vomitting almost immediately after eating. While Phenergan contains Promethazine which is Antihistamine and also act ant vomiting agent Dose of Zofran for Nausea 4-8 mg It is taken by mouth every 6 hours, as needed While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy. Zofran is a class b drug, safe during pregnancy, phenergan is a class c drug, the effects are unknown. Most people for the record are given Phenergan or promethazine Tablets first and if that does not work they got to the Zofran not only for more effect but the Zofran is much more expensive than the Phenergan. My daughter uses Zofran if she catches the nausea early enough to try and avoid vomiting AND if it diring the day. While Phenergan contains Promethazine which is Antihistamine and also act ant vomiting agent.. Zofran is available as tablets, dissolvable tablets, strips, or liquid. While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy. Side effects of ondansetron and promethazine that are similar include drowsiness and sedation, constipation, and dizziness. The authors used a 15-mm margin of noninferiority. I''m not exactly sure how Reglan works. They both are for nausea or vomiting and can help with some dizziness also. Sedation is the main side effect. Results: A total of 120 subjects completed the study, 60 in each arm What is the best medicine for nausea/vomitting -- Zofran, Reglan or Phenergan? 5k views Reviewed >2 years ago. For evenings and in the middle of episodes, she takes Phenergan as she usually sleeps off episodes-- for her, it helps to abort more nausea better than Zofran when in the middle of an episode while helping her get to go to sleep faster and better than just waiting it out Jun 24, 2014. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy. One of the most effective anti-nausea medications is Zofran (ondansetron) which was developed to solve this problem. Zofran (ondansetron) works well to prevent nausea and vomiting. I would personally never take phenergan during pregnancy, I would rather deal with the nausea than take the risk. Zofran has safer side effect profile They both are for nausea or vomiting and can help with some dizziness also. 2 thanks Regarding your concern I want to share with you that,Zofran contains , Ondansetron is an antiemetic (anti-nausea medicine). The reduction in anxiety was similar (ondansetron -13 mm, promethazine -14 mm; difference -1 mm; 95% CI = -10 to 10 mm) Drink it strong: Ginger can reduce nausea & upset stomach. Evidence shows that the outcome at 30 minutes after administration the outcome between zofran and phenergan are equal for relief of nausea. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis more Prescription only. Or pour boiling water over Read More. Analyses included t-tests, tests for proportions, and 95% confidence intervals (CIs). John Munshower and 2 doctors agree. Ondansetron is an anti-nausea medication and promethazine is a phenothiazine.